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Usefulness of Thromboelastography as a Predictor of Prognosis in Patients Undergoing Surgery for Glial Tumors and of the Risk of Postoperative Thromboembolic Disease (GliTEM)

NCT07813377

RecruitingN/A

Sponsor: Fundacion Clinic per a la Recerca Biomédica

Conditions: Glial Tumors, Thrombosis, Pulmonary Embolism (Diagnosis)

Interventions: Thromboelastometry values: EXTEM CT, MCF, α-angle below the lower limit of normal. Measurement obtained after anesthetic induction. - PT, aPTT, fibrinogen, platelet count. - Thrombin generation. -

Countries: Spain

The objective of our study is to investigate the clinical significance of thromboelastometric values in the development of thrombotic events and survival in patients with glial tumors, to reduce thromboembolic complications and optimize oncological treatment.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patients undergoing surgical excision or biopsy with a diagnostic impression of glial tumor who provide written informed consent

Exclusion Criteria:

* Patients under 18 years of age.
* Emergency surgery.
* Patients receiving antiplatelet or anticoagulant treatment.
* Patients with known hematologic diseases associated with coagulation abnormalities. Examples include:

  * Congenital or acquired platelet function disorders.
  * Congenital deficiency of protein C or protein S.
  * Deficiency of coagulation factors II, V, VII, X, XII.
  * Glanzmann thrombasthenia.
  * Hemophilia A, B, or C.
  * Idiopathic thrombocytopenic purpura (ITP).
  * von Willebrand disease (types I, II, and III).
* Systemic diseases that cause significant coagulation time alterations:

  * Prothrombin time \< 60%.
  * Activated partial thromboplastin time (aPTT) \> 50 seconds.
* Patients with suspected glial or neuroglial tumor in the context of long-standing epilepsy

Locations (1)

Barcelona, Spain