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Multimodal Biomarkers in Individual With Cognitive Impairment and Dementia

Not Yet RecruitingN/A

Sponsor: Assiut University

Conditions: Dementia Disorders, Mild Cognitive Impairment (MCI)

Memory problems can range from normal aging to mild cognitive impairment (MCI) to dementia. This study looks at three ways of measuring what is happening in the brain at each of these stages: a blood test (GFAP), a brain MRI scan, and a brain wave test (EEG). The goal is to see whether combining these three tests can help doctors tell the difference between normal aging, MCI, and dementia more accurately, and whether this approach works well in an Egyptian population, including all common causes of dementia (not only Alzheimer's disease). Adults aged 50 to 85 will be placed into one of three groups: those with normal memory, those with mild memory problems (MCI), and those with dementia. Everyone will have a memory and thinking assessment, a blood draw, a brain MRI, and a brain wave (EEG) recording. No new medication or treatment is given as part of this study; it involves only assessment and testing. The information gathered may help doctors diagnose memory problems earlier and more accurately in the future.

Eligibility overview

Sex: ALL

Age: 50 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. Dementia diagnosed according to DSM -5\\ with a total Mini-Mental State Examination score \< 24 (or \< 22 according to educational state), together with a Modified Mini-Mental State Examination (3MS) score \< 79 to confirm cognitive impairment.
2. Mild cognitive impairment diagnosed according to established diagnostic criteria according to DSM -5.
3. Men or women of at least 50 years of age.
4. Reliable in individual data and willing to make themselves available for the duration of the study.
5. Clear written informed consent obtained from a first-degree relative for each patient participant, and from the control participant himself/herself.

Exclusion Criteria:

* age below 50 years .

  * other neurological disorders or psychiatric disorders; previous history of stroke; metabolic disturbance; other major medical illnesses; epilepsy; inflammatory, autoimmune, or infectious disease; metallic objects in the body; craniotomy in the past.
  * Presence of clinically significant medical or psychiatric condition that may increase the risk associated with the study
  * MRI contraindication (pacemaker, metallic implants, severe claustrophobia).