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Extended Validation of Donor-derived Cell-free DNA in Kidney Transplant Recipients
Extended Validation of Donor-derived Cell-free DNA in Kidney Transplant Recipients

NCT07805343

Active Not RecruitingN/A

Sponsor: Paris Translational Research Center for Organ Transplantation

Conditions: Rejection Acute Renal, Rejection Chronic Renal, Transplantation, Kidney Rejection Transplant

Interventions: Donor-derived cell-free DNA

Countries: United States, Belgium, Brazil, France, Germany, South Korea, Spain, Switzerland

This is a multinational, multi-center, observational cohort study. Kidney allograft rejection is poorly detected by standard-of-care biomarkers. Although dd-cfDNA has been associated with improved rejection detection when added to standard-of-care biomarkers and clinical parameters, little is known about its performance across Banff 2022 rejection phenotypes and injury patterns, in various clinical scenarios and populations, and when measured repeatedly over time.

Eligibility overview

Sex: ALL

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria
Inclusion Criteria:

* Recipients transplanted from a deceased or living donor
* Kidney allograft biopsy concomitantly with dd-cfDNA measurement
* Written informed consent at the time of transplantation for inclusion the center database

Exclusion Criteria:

* Combined organ transplantation
* Pregnant women
* Grafts from monozygotic twins
* Recipient of a bone marrow transplant
Locations (25)
  • Los Angeles, California, United States
  • Los Angeles, California, United States
  • Los Angeles, California, United States
  • Tampa, Florida, United States
  • Atlanta, Georgia, United States
  • St Louis, Missouri, United States
  • St Louis, Missouri, United States
  • New York, New York, United States
  • Cleveland, Ohio, United States
  • Dallas, Texas, United States
  • Murray, Utah, United States
  • Salt Lake City, Utah, United States
  • Richmond, Virginia, United States
  • Madison, Wisconsin, United States
  • Leuven, Belgium
  • São Paulo, Brazil
  • Paris, France
  • Paris, France
  • Paris, France
  • Paris, France
  • Toulouse, France
  • Berlin, Germany
  • Seoul, South Korea
  • Barcelona, Spain
  • Geneva, Switzerland