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Postoperative Analgesic Consumption After Preoperative Gabapentin vs Placebo in Breast Cancer Surgery

CompletedNA

Sponsor: Shaukat Khanum Memorial Cancer Hospital & Research Centre

Conditions: Breast Cancer Surgery Pain

Interventions: Oral Gabapentin pre-op, Vitamin B complex tablets (Neurorubine TM -Forte Lactab TM)

Countries: Pakistan

The study will be conducted after approval from the Scientific and Ethical Review Committees. Eligible patients will be enrolled after obtaining written informed consent and randomly allocated to Group A (gabapentin) or Group B (placebo). Group A will receive oral gabapentin 600 mg one hour before surgery, while Group B will receive oral placebo (sodium bicarbonate) at the same time. General anesthesia will be induced with propofol, atracurium, and fentanyl and maintained with sevoflurane using a supraglottic airway device. Both groups will receive IV paracetamol, ketorolac, and local bupivacaine infiltration. Intraoperative rescue analgesia with IV morphine will be given if hemodynamic parameters increase by \>20% from baseline. Postoperatively, patients will be monitored in the recovery area for pain using the Numeric Rating Scale (NRS) and for adverse effects including drowsiness, nausea, and vomiting. IV morphine 0.1 mg/kg will be administered if the NRS pain score is \>2. The total morphine consumption during recovery will be recorded for both groups. Data will be collected using the attached proforma.

Eligibility overview

Sex: FEMALE

Age: 18 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

1. Age between 18 to 60 years.
2. Female Gender
3. American Society of Anesthesiologists grade 1 and 2 patients.
4. Elective breast surgery
5. Admitted and day case surgeries

Exclusion Criteria:

1. Patients allergic to gabapentin
2. Patients refusal.
3. Patients having a history of chronic pain.
4. Patients already using opioids for pain control

Locations (1)

Lahore, Punjab Province, Pakistan