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The Effect of Mindfulness in Inflammation Markers (MLR, NLR, PLR), Stress, Anxiety, and Depression Rate Among Survivors of Tidal Flooding in Sayung Demak

NCT07796919

Not Yet RecruitingNA

Sponsor: Natalia Dewi Wardani, MD

Conditions: Psychological Stress, Depression - Major Depressive Disorder, Anxiety, Post-traumatic Stress Symptoms, Inflammation

Interventions: Mindfulness Body Scan

Countries: Indonesia

Tidal flood disasters in coastal areas cause chronic psychological stress due to economic, social, and residential disruption. Psychological stress is closely linked to systemic inflammatory responses-marked by elevated Monocyte-to-Lymphocyte Ratio (MLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR)-which are associated with depression and anxiety symptoms. Mindfulness interventions, particularly body scan techniques, have been shown to reduce psychological distress and modulate immune responses, but empirical evidence on coastal flood survivors in Indonesia remains limited. This study aims to evaluate the effectiveness of a community-based mindfulness body scan intervention on inflammatory biomarkers (MLR, NLR, PLR) and psychological parameters (stress, depression, anxiety, trauma, sleep quality, and resilience) among tidal flood survivors in Sayung, Demak. Participants will undergo baseline blood work and psychometric assessments, receive an 8-day mindfulness body scan intervention, and complete post-intervention evaluations.

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Adults aged 18 to 60 years.
* Survivors of tidal flooding (bencana rob) residing in the Sayung coastal area for at least 6 months.
* Minimum educational attainment of Primary School (Sekolah Dasar / SD).
* Literate in Indonesian (able to read and write).
* Willing to participate in and complete the 8-day mindfulness intervention program.
* Physically independent and capable of completing self-administered questionnaires.

Exclusion Criteria:

* Active psychotic disorders or severe mental illness.
* Cognitive impairment that limits ability to complete assessments.
* History of diagnosed autoimmune disorders, active allergies, or chronic inflammatory diseases.
* Presence of acute infectious disease symptoms within the past 1 month.
* Currently undergoing formal psychotherapy or other structured psychological interventions.

Locations (1)

Demak, Central Java, Indonesia