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New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease

RecruitingNA

Sponsor: Indiana University

Conditions: HIV, Kaposi Sarcoma Herpesvirus -Associated Multicentric Castleman Disease, Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Tiny Isothermal Nucleic Acid Amplification System

Interventions: Lymph Node or Core Needle Biopsy, Fine Needle Aspiration, Tiny Isothermal Nucleic acid Amplification System (TINY)

Countries: Malawi

Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.

Eligibility overview

Sex: ALL

Age: 1 Year to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age ≥1 year old and body weight of ≥ 10 kg.
* HIV-infected.
* Unexplained lymphadenopathy with at least one lymph node ≥2 cm that is amenable to biopsy.
* Willing and able to give informed consent if the subject is 18 years of age or older, adolescent assent and legal guardian consent for subjects 15-17 years of age, pediatric assent and legal guardian consent for subjects 7-14 years of age, or legal guardian consent for pediatric subjects less than 7 years of age.

Exclusion Criteria:

* Cannot or is not willing to follow study procedures.
* Subjects with a previous history of cancer in the last five years with the exception of subjects with Kaposi sarcoma (i.e. history of Kaposi sarcoma is allowed in the study).

Locations (1)

Lilongwe, Malawi