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Inclusion Criteria:

* Provided written Informed Consent.
* Patient is willing and able to comply with study protocol, visit schedule, and other study-related instructions/procedures, including in-clinic stay as required.
* Patient is a male or non-pregnant female 18 to 85 years of age (inclusive) at Screening.
* Patient has either 4 or more AK lesions on the upper extremities; or 6 or more AK lesions on the face. Lesions must be within an area of 25 cm2.
* Patient is in good general health and free of any disease state or physical condition.
* Patient has veins suitable for repeat blood draws.
* Patient is willing to abstain from sunbathing, solarium use, exposure to artificial tanning devices.
* Patient is willing to follow a consistent skin care routine without significant change.
* Patient is willing to stop using all topical products within the Treatment Area(s) starting from 8 hours prior to initiation of treatment.
* Patients who are women of childbearing potential must agree to use a highly effective method of contraception during the study.
* Patients who are male with female partners of childbearing potential must use a barrier method of contraception (e.g., condom) if not surgically sterile.
* Females of childbearing potential must have a negative serum pregnancy test at Screening and a negative urine pregnancy test before initiation of treatment at Baseline.

Exclusion Criteria:

* Patient is pregnant, lactating, or is planning to become pregnant during the study.
* Patient has severe AK lesions within the Treatment Area.
* Patient has untreated skin cancers or lesions suspicious for skin cancer within the Treatment Area.
* Patient has an active herpes simplex infection OR a history of ≥2 outbreaks within past 12 months in the Treatment Area.
* Patient has significant skin abnormality involving the Treatment Area
* Patient has a history of skin sensitivity to light.
* Patient has known hypersensitivity to one or more components of the IP.
* Patient has a history of lead poisoning or a history of significant exposure to lead.
* Patient smokes more than 10 cigarettes/day.
* Patient has a suppressed immune system.
* Patient has a coagulation defects.
* Patient has a Body Mass Index (BMI) \> 32.0 kg/m2.
* Patient has donate blood recently.
* Patient is positive for HIV, Hepatitis B and/or Hepatitis C.
* Patient has history of alcohol or drug abuse during the past year prior.
* Patient has a positive urine screen for drugs of abuse.
* Patient has abnormal labs at Screening.
* Patient had a major surgery within 30 days or plans to have surgery during the study.
* Patient has any condition which would make it unsafe for the patient to participate in this research study or interferes with assessment/interpretation of study outcomes.
* Patient received any topical or systemic therapies on the Treatment Area within a certain amount of time.
* Patient is currently enrolled in an investigational drug, investigational biologic, or investigational device study.
* Patient has received an investigational drug, investigational biologic, or investigational device treatment within 30 days or 5 half-lives of the experimental agent, whichever is longer, prior to initiation of treatment at Baseline.

• College Station, Texas, United States