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De-escalation of RNI in Breast Cancer Patients With pN0 After Neoadjuvant Therapy

Not Yet RecruitingNA

Sponsor: Aya Ahmed Sayed

Conditions: Breast Cancer

Interventions: Adjuvant Radiotherapy

Prospective Comparative Study of Response-Adapted De-escalation of Regional Nodal Irradiation in Initially Node Positive Breast Cancer Patients with Pathological Nodal Complete Response After Neoadjuvant Therapy

Eligibility overview

Sex: FEMALE

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Female patients \>= 18 years old.
* Histologically confirmed invasive breast cancer, cT1-3 N1M0 according to the 8th AJCC edition.
* Biopsy-proven cN1 disease at diagnosis.
* Completion of standard neoadjuvant systemic therapy.
* Surgical treatment of breast and axilla.
* Pathologically confirmed ypN0 status.
* ECOG performance status 0-2.
* Suitable for adjuvant radiotherapy.
* Signed informed consent.

Exclusion Criteria:

* Metastatic disease (M1).
* Prior thoracic irradiation.
* Pregnancy or lactation.
* Severe uncontrolled comorbid illness.
* Any contraindication to radiotherapy.