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AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

NCT07720271

Not Yet RecruitingPhase 3

Sponsor: Novo Nordisk A/S

Conditions: Overweight, Obesity

Interventions: zenagamtide, Placebo

Countries: United States

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Male or female (sex at birth).
* Age 18 and older (both inclusive) at time of signing the informed consent.

Exclusion Criteria:

* Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening.
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
* Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
Locations (42)
  • Anniston, Alabama, United States
  • Birmingham, Alabama, United States
  • Montgomery, Alabama, United States
  • Fullerton, California, United States
  • Lomita, California, United States
  • Walnut Creek, California, United States
  • Aurora, Colorado, United States
  • Delray Beach, Florida, United States
  • Fleming Island, Florida, United States
  • Hialeah, Florida, United States
  • Jacksonville, Florida, United States
  • Miramar, Florida, United States
  • Orlando, Florida, United States
  • Orlando, Florida, United States
  • Oviedo, Florida, United States
  • Conyers, Georgia, United States
  • Honolulu, Hawaii, United States
  • Chicago, Illinois, United States
  • Gurnee, Illinois, United States
  • Skokie, Illinois, United States
  • Skokie, Illinois, United States
  • Indianapolis, Indiana, United States
  • Buckley, Michigan, United States
  • City of Saint Peters, Missouri, United States
  • Las Vegas, Nevada, United States
  • New York, New York, United States
  • Chapel Hill, North Carolina, United States
  • Greensboro, North Carolina, United States
  • Raleigh, North Carolina, United States
  • Salisbury, North Carolina, United States
  • + 12 more on CT.gov