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Midlife Empowerment and Longevity Through Optimizing Wellness

Not Yet RecruitingNA

Sponsor: National University Health System, Singapore

Conditions: Menopause

Interventions: MELOW

The goal of this observational longitudinal study is to understand how lifestyle behaviours, menopausal symptoms, and digital health data change over time in women experiencing perimenopause or menopause, and to evaluate whether a personalised digital health programme can support healthier lifestyle behaviours and improve cardiometabolic health. The main questions it aims to answer are: 1. Can personalised lifestyle recommendations informed by wearable devices, dietary logging, and self-reported symptoms improve adherence to healthy diet, physical activity, and sleep behaviours? 2. How are menopausal symptoms associated with changes in cardiometabolic health, body composition, physical function, and quality of life over time? Participants will: 1. Attend study visits at the National University of Singapore for health assessments, including measurements of body composition, physical function, and cardiometabolic health. 2. Wear a smartwatch or wearable device to monitor physiological and activity data throughout the study. 3. Use a mobile application to record dietary intake, menopausal symptoms, and other health-related information. 4. Receive personalised lifestyle recommendations based on their health data and engage in regular follow-up assessments over the study period.

Eligibility overview

Sex: FEMALE

Age: 21 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Women aged 21-65 years old;
* Report at least mild climacteric symptoms as indicated by an MRS score ≥5;
* Waist circumference ≥80 cm, indicating abdominal adiposity;
* Own and use a smartphone compatible with the CGM and Oura Ring.

Exclusion Criteria:

* Are currently receiving hormone replacement therapy (HRT);
* Are currently using oral contraceptives;
* Have been diagnosed with severe psychiatric illness requiring inpatient care;
* Are concurrently enrolled in another behavioural or psychotherapy trial;
* Have significant cognitive impairment or inability to engage with digital tools;
* Have uncontrolled chronic medical conditions that may interfere with study participation;
* Unable to comprehend written and spoken English.