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TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies

NCT07692217

Not Yet RecruitingN/A

Sponsor: University of Texas Southwestern Medical Center

Conditions: Hemophilia A, Factor VIII (FVIII)

Interventions: Half-life factor VIII based replacement therapy, Non-FVIII based replacement therapy

Countries: United States

This is an observational research study to find out if there is a difference in the way children with moderate or severe hemophilia A, treated on two different types of factor replacement, form a clot and also evaluate if they develop tiny bleeds within the joint and subsequently early joint changes when receiving extended half-life factor VIII.

Eligibility overview

Sex: ALL

Age: 6 Months to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Participants with moderate or severe HA who are on prophylaxis with either weekly, biweekly, or every 4-weeks emicizumab or weekly efanesoctocog alfa for at least 2 months.
* \>6 months of age

Exclusion Criteria:

* Participants with active FVIII inhibitor (\>0.5 BU/mL)
* Presence of an additional bleeding disorder other than hemophilia A

Locations (1)

Dallas, Texas, United States