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Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement

NCT07690865

Not Yet RecruitingNA

Sponsor: Chang Gung Memorial Hospital

Conditions: Gamma Oscillations, Healthy Adults, Alzheimer's Disease (AD), Gamma Entrainment Using Sensory Stimuli (GENUS)

Interventions: Personalized optimal gamma auditory frequency stimulation, Non-optimal gamma auditory frequency stimulation

Countries: Taiwan

This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization. While 40 Hz auditory stimulation has been widely studied, recent evidence suggests optimal frequencies vary by individual. Using a cross-over design with 20 healthy adults, the research compares "optimal" versus "non-optimal" frequencies over one-month intervention periods. Effectiveness is measured through EEG recordings and executive function tasks. The goal is to determine if personalized sensory intervention provides a more effective, non-invasive strategy for enhancing cognitive performance.

Eligibility overview

Sex: ALL

Age: 18 Years to 40 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

1. Age between 18 to 40 years old.
2. The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education.
3. Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function.
4. Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.).
5. Participants with normal or corrected vision (e.g., glasses or contact lenses) to normal levels.
6. Auditory stimuli induce significant neural entrainment.
7. Self-reported normal hearing

Exclusion Criteria:

1. Participants enrolled in any cognitive enhancement study within the past two months.
2. Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.).
3. Individuals with tinnitus or hyperacusis

Locations (1)

Taoyuan, Guishan, Taiwan