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The Impact of Anxiety/Depression on the Efficacy of Asthma Control Drugs and the Construction of a Predictive Model for the Risk of Acute Asthma Attacks

NCT07679321

RecruitingN/A

Sponsor: Xiangya Hospital of Central South University

Conditions: Anxiety/Depression and Asthma

Interventions: No intervention measures

Countries: China

The goal of this clinical trial is to explore the impact of anxiety/depression on the efficacy of asthma controller medications and to develop a risk prediction model for asthma acute exacerbations in patients with asthma. It will also analyze the association between anxiety/depression severity and asthma severity. The main questions it aims to answer are: Does anxiety/depression affect the therapeutic effect of asthma controller medications (e.g., asthma control level)? Can a reliable risk prediction model for asthma acute exacerbations be established based on anxiety/depression and other relevant factors? Researchers will conduct a prospective observational study to collect and analyze data from participants, without additional interventions beyond standard clinical care, to explore the above research questions. Participants will: Complete baseline assessments, including demographic information collection, medical history review, lung function tests, anxiety/depression evaluations (via GAD-7 and PHQ-9 scales), and provide biological samples (induced sputum, feces, blood) Undergo follow-up visits at 3, 6, 12, 18, and 24 months after baseline Report asthma symptoms, acute exacerbation events, and cooperate with required clinical checkups during follow-up

Eligibility overview

Sex: ALL

Age: 14 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosis of asthma according to the Global Initiative for Asthma (GINA) 2024 criteria.
* Male or female patients aged 14 years or older.
* Complete clinical data available.
* Newly diagnosed asthma or stable asthma.
* Receiving asthma controller medication.

Exclusion Criteria:

* History of major lung diseases other than asthma, congestive heart failure, cor pulmonale, or recent cardiac or thoracic surgery.
* Incomplete medical records.
* Cognitive impairment or inability to complete psychological scale assessments.
* Clinically diagnosed acute or chronic mental disorders, such as bipolar disorder or schizophrenia.
* Current use of antidepressant or anti-anxiety medications.
* Pregnancy or lactation.

Locations (1)

Changsha, Hunan, China