Trial Radar
Sign in

NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

NCT07595549

RecruitingPhase 3

Sponsor: Pfizer

Conditions: Obesity, Overweight and/or Obesity, Overweight

Interventions: PF-08653944, Placebo

Countries: United States, Japan

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Aged ≥18 years.
* BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to \<30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D.

Exclusion Criteria:

* Have a self-reported body weight change greater than 5% within 90 days prior to Screening.
* Diagnosis of type 1 diabetes or any other form of diabetes other than T2D.
* History of acute or chronic pancreatitis.
* Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).
Locations (25)
  • Modesto, California, United States
  • Roseville, California, United States
  • Sacramento, California, United States
  • Tustin, California, United States
  • Walnut Creek, California, United States
  • Crystal River, Florida, United States
  • Lecanto, Florida, United States
  • Miramar, Florida, United States
  • New Port Richey, Florida, United States
  • New Port Richey, Florida, United States
  • Evansville, Indiana, United States
  • Louisville, Kentucky, United States
  • Flint, Michigan, United States
  • Albuquerque, New Mexico, United States
  • Rochester, New York, United States
  • Greensboro, North Carolina, United States
  • Cincinnati, Ohio, United States
  • Cincinnati, Ohio, United States
  • San Antonio, Texas, United States
  • Norfolk, Virginia, United States
  • Suita, Osaka, Japan
  • Chuo-ku, Tokyo, Japan
  • Chuo-ku, Tokyo, Japan
  • Chuo-ku, Tokyo, Japan
  • Shinjuku-ku, Tokyo, Japan