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A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

RecruitingPhase 2

Sponsor: Pfizer

Conditions: Overweight, Obesity, Overweight and/or Obesity, Overweight or Obesity, Overnutrition

Interventions: PF-08653945, PF-08653944, Placebo

Countries: United States, Canada

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

Eligible participants for this study include:

* adults aged 18 years or older with
* obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with
* overweight (BMI of 27.0 kg/m2 to \<30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.

Exclusion Criteria:

Participants who are not eligible include those with diabetes mellitus, a body weight change of \>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.

Locations (65)

Chandler, Arizona, United States
Sun City West, Arizona, United States
Tucson, Arizona, United States
Canoga Park, California, United States
Fountain Valley, California, United States
Garden Grove, California, United States
Lomita, California, United States
Long Beach, California, United States
Los Alamitos, California, United States
Modesto, California, United States
San Diego, California, United States
Tustin, California, United States
Walnut Creek, California, United States
Hialeah, Florida, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Orlando, Florida, United States
Atlanta, Georgia, United States
Stockbridge, Georgia, United States
Morton, Illinois, United States
Naperville, Illinois, United States
Lenexa, Kansas, United States
Mandeville, Louisiana, United States
Prairieville, Louisiana, United States
Lutherville, Maryland, United States
Springfield, Missouri, United States
Butte, Montana, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
+ 35 more on CT.gov