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Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

NCT07575399

RecruitingPhase 3

Sponsor: Amgen

Conditions: Obesity or Overweight

Interventions: Maridebart Cafraglutide

Countries: United States, Puerto Rico

Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.

Eligibility overview

Sex: ALL

Age: 18 Years to 99 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Body Mass Index (BMI) ≥ 25 at screening.
* Weight loss of ≥ 10% on weekly GLP-1 RA.
* Stable body weight.
* Stable dose of GLP-1RA.
* Stable gastrointestinal (GI) tolerability.
* Contraception for females.
* Willingness to follow trial procedures for the duration of the trial.

Exclusion Criteria:

* Obesity induced by other endocrine disorders (ex: Cushing's syndrome).
* Previous or planned surgical, endoscopic or device-based treatment for obesity.
* History of malignancy.
* Type 1/Type 2 diabetes mellitus (DM).
* Family or personal history of medullary thyroid cancer.
* Previous participation in a Maridebart Cafraglutide trial.
Locations (44)
  • Pelham, Alabama, United States
  • Chandler, Arizona, United States
  • Sun City, Arizona, United States
  • Palm Springs, California, United States
  • Rialto, California, United States
  • Rolling Hills Estates, California, United States
  • San Diego, California, United States
  • Santa Ana, California, United States
  • Gainesville, Florida, United States
  • Hialeah, Florida, United States
  • Margate, Florida, United States
  • Miami, Florida, United States
  • Miami, Florida, United States
  • Orlando, Florida, United States
  • Orlando, Florida, United States
  • Port Orange, Florida, United States
  • The Villages, Florida, United States
  • Johns Creek, Georgia, United States
  • Union City, Georgia, United States
  • Woodstock, Georgia, United States
  • Meridian, Idaho, United States
  • Skokie, Illinois, United States
  • Baton Rouge, Louisiana, United States
  • Troy, Michigan, United States
  • Ridgeland, Mississippi, United States
  • Las Vegas, Nevada, United States
  • New York, New York, United States
  • Rochester, New York, United States
  • Morehead City, North Carolina, United States
  • Raleigh, North Carolina, United States
  • + 14 more on CT.gov