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Sponsor: West Kazakhstan Marat Ospanov Medical University
Conditions: Diabetes Mellitus, Type 2, Autoimmune Diabetes
Countries: Kazakhstan
The goal of this observational study is to better understand how diabetes develops in adults at the time of diagnosis. The study focuses on adults with newly diagnosed diabetes in the Kazakh population. The main questions it aims to answer are: * How do insulin resistance and beta-cell function differ between participants? * How is the immune system involved at the early stage of diabetes? * How are inflammation markers related to metabolic changes? Participants undergo clinical and laboratory assessments at diagnosis. These include: * Measurement of body mass index (BMI) and blood glucose control (HbA1c) * Assessment of insulin resistance and beta-cell function using HOMA2 indices * Measurement of C-peptide levels * Testing for islet autoantibodies (GADA, IA-2A, ZnT8A, ICA) * Measurement of inflammatory markers, including interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) This study aims to improve understanding of different forms of adult-onset diabetes and support more personalized approaches to diagnosis and treatment.
Sex: ALL
Age: 25 Years to 75 Years
Healthy volunteers: No
Study type: OBSERVATIONAL
Inclusion Criteria: * Adults aged 25 years and older * Kazakh population with newly diagnosed diabetes mellitus * Diagnosis established in routine clinical practice * No prior insulin therapy at the time of enrollment * No prior use of glucose-lowering therapy beyond initial management * Ability and willingness to provide informed consent Exclusion Criteria: * Clinical features suggestive of classical type 1 diabetes at presentation * History of long-term insulin therapy prior to enrollment * Severe acute illness or infection at the time of assessment * Pregnancy * Incomplete clinical or laboratory data
- Aktobe, Kazakhstan