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Nicorandil as Anti-inflammatory in Rheumatoid Arthritis

RecruitingPhase 3

Sponsor: Tanta University

Conditions: Rhumatoid Arthisis

Interventions: Nicorandil 5 MG Oral Tablet

Countries: Egypt

This study aims to evaluate the possible efficacy and safety of nicorandil as anti-inflammatory in managing patients with active rheumatoid arthritis.

Eligibility overview

Sex: ALL

Age: 18 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Patients with active rheumatoid arthritis (not in remission) according to American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) i.e., 28 joints disease activity score (DAS-28) \>2.6.
* Patients receiving the conventional DMARDs

Exclusion Criteria:

* Patients with heart disease (congestive heart failure, arrhythmia and ischemic heart disease), diabetes, active infection, and other illness except rheumatoid arthritis.
* Patients with severe renal and hepatic dysfunction. - Patients receiving biological DMARDs.
* Patients receiving oral prednisolone greater than 15mg/day.
* Patients with hypersensitivity to study medications.
* Patients using antioxidants.
* Pregnant and lactating females.

Locations (1)

Tanta, Gharbia Governorate, Egypt