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A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

NCT07477704

RecruitingPhase 2

Sponsor: Regeneron Pharmaceuticals

Conditions: Hypercholesterolemia

Interventions: Alirocumab

Countries: United States

This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels). The aim of the study is to see how safe and effective alirocumab is when given weekly to adult participants who have hypercholesterolemia. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug once a week * How much study drug is in the blood at different times

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Key Inclusion Criteria:

1\. Participant has elevated LDL-C level, as defined in the protocol

Key Exclusion Criteria:

1. Participant plans to initiate or change dose of lipid-lowering therapy
2. Use of any PCSK9 inhibitors

NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply
Locations (34)
  • Anniston, Alabama, United States
  • Cullman, Alabama, United States
  • Anaheim, California, United States
  • Los Alamitos, California, United States
  • Walnut Creek, California, United States
  • Clearwater, Florida, United States
  • Fort Myers, Florida, United States
  • Sunrise, Florida, United States
  • The Villages, Florida, United States
  • Gainesville, Georgia, United States
  • Lawrenceville, Georgia, United States
  • Honolulu, Hawaii, United States
  • Louisville, Kentucky, United States
  • Marrero, Louisiana, United States
  • Butte, Montana, United States
  • Omaha, Nebraska, United States
  • Las Vegas, Nevada, United States
  • Durham, North Carolina, United States
  • Wilmington, North Carolina, United States
  • Columbus, Ohio, United States
  • Norman, Oklahoma, United States
  • Oklahoma City, Oklahoma, United States
  • Medford, Oregon, United States
  • Duncansville, Pennsylvania, United States
  • Greenville, South Carolina, United States
  • North Charleston, South Carolina, United States
  • Dallas, Texas, United States
  • Fort Worth, Texas, United States
  • Round Rock, Texas, United States
  • San Antonio, Texas, United States
  • + 4 more on CT.gov