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A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

NCT07415031

RecruitingPhase 2

Sponsor: Mirati Therapeutics Inc.

Conditions: Solid Tumors

Interventions: Adagrasib, Pembrolizumab, Cetuximab, Pemetrexed, Docetaxel

Countries: United States, Australia, Belgium, Canada, China, France, Germany, Greece

This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit.
* Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF.

Exclusion Criteria:

* Participant is not eligible for study treatment per the parent study eligibility criteria.
* Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study.
* Participants not receiving clinical benefit from parent study drug as assessed by the investigator.

Other protocol defined inclusion/exclusion criteria applies.
Locations (101)
  • Phoenix, Arizona, United States
  • Bellflower, California, United States
  • Long Beach, California, United States
  • Newark, Delaware, United States
  • St. Petersburg, Florida, United States
  • Wichita, Kansas, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • Rochester, Minnesota, United States
  • Saint Paul, Minnesota, United States
  • Omaha, Nebraska, United States
  • Eugene, Oregon, United States
  • Germantown, Tennessee, United States
  • Bedford, Texas, United States
  • Dallas, Texas, United States
  • Grapevine, Texas, United States
  • Bellingham, Washington, United States
  • St Leonards, New South Wales, Australia
  • Ghent, Belgium
  • Vancouver, British Columbia, Canada
  • Beijing, Beijing Municipality, China
  • Xiamen, Fujian, China
  • Zhengzhou, Henan, China
  • Changsha, Hunan, China
  • Nanjing, Jiangsu, China
  • Nanchang, Jiangxi, China
  • Shenyang, Liaoning, China
  • Jinan, Shandong, China
  • Linyi, Shandong, China
  • Shanghai, Shanghai Municipality, China
  • + 71 more on CT.gov