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A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis

NCT07412704

Not Yet RecruitingPhase 1, Phase 2

Sponsor: Bristol-Myers Squibb

Conditions: Arthritis, Rheumatoid

Interventions: BMS-986528

Countries: United States, Belgium, Brazil, China, Germany, Hungary, Italy, Mexico

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modifying effect of BMS-986528 in participants with refractory, difficult-to-treat rheumatoid arthritis (RA).

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria

\- Adult participants with rheumatoid arthritis (RA) who meet definition of difficult-to-treat.

Exclusion Criteria

* Juvenile arthritis or onset of inflammatory arthritis before age 18.
* Seronegative RA participants in whom polymyalgia rheumatica has not been ruled out.
* Active fibromyalgia with pain symptoms or signs that would interfere with joint assessment.
* Other protocol-defined Inclusion/Exclusion criteria apply.
Locations (43)
  • La Jolla, California, United States
  • Loma Linda, California, United States
  • Palo Alto, California, United States
  • Aurora, Colorado, United States
  • Denver, Colorado, United States
  • South Miami, Florida, United States
  • New York, New York, United States
  • New York, New York, United States
  • Portland, Oregon, United States
  • Philadelphia, Pennsylvania, United States
  • DeSoto, Texas, United States
  • San Antonio, Texas, United States
  • Merksem, Flanders, Belgium
  • Leuven, Belgium
  • Aparecida de Goiânia, Goiás, Brazil
  • Porto Alegre, Rio Grande do Sul, Brazil
  • Valinhos, São Paulo, Brazil
  • Beijing, Beijing Municipality, China
  • Guangzhou, Guangdong, China
  • Zhengzhou, Henan, China
  • Nanchang, Jiangxi, China
  • Shanghai, Shanghai Municipality, China
  • Shanghai, Shanghai Municipality, China
  • München, Bavaria, Germany
  • Berlin, Germany
  • Cologne, Germany
  • Herne, Germany
  • Potsdam, Germany
  • Sendenhorst, Germany
  • Budapest, Hungary
  • + 13 more on CT.gov