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DESTINY-PANTUMOUR04
DESTINY-PANTUMOUR04

NCT07124000

RecruitingN/A

Sponsor: AstraZeneca

Conditions: Adenocarcinoma (NOS), Anal Cancer, Bladder Cancer, Cervical Cancer, Endometrial Cancer

Interventions: Trastuzumab deruxtecan

Countries: United States

This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options in a real-world setting in the US

Eligibility overview

Sex: ALL

Age: 18 Years to 130 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria
Inclusion Criteria:

1. Adults aged ≥18 years
2. Patients with locally advanced, unresectable, or metastatic HER2-positive (IHC 3+) solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options as determined by the Investigator (see Exclusion Criterion 1 for excluded solid tumors);
3. A clinician decision has been made for treatment with T-DXd in accordance with the FDA label;
4. HER2-positive (IHC 3+) by local testing prior to study enrolment at the time of signed and dated informed consent;
5. Patients who are willing and able to provide a signed and dated informed consent.

Exclusion Criteria:

1. Primary diagnosis of adenocarcinoma of the breast, adenocarcinoma of the colon or rectum, NSCLC, adenocarcinoma of the gastric body or gastroesophageal junction or hematological malignancies;
2. Prior T-DXd therapy;
3. Patients without a baseline assessment of tumor burden undertaken prior to initiating T-DXd.
4. Patient is participating in a clinical trial at time of enrolment
Locations (18)
  • Birmingham, Alabama, United States
  • Bullhead City, Arizona, United States
  • Casa Grande, Arizona, United States
  • San Diego, California, United States
  • Boulder, Colorado, United States
  • Coral Springs, Florida, United States
  • St. Petersburg, Florida, United States
  • West Palm Beach, Florida, United States
  • Decatur, Illinois, United States
  • Topeka, Kansas, United States
  • Farmington, New Mexico, United States
  • Durham, North Carolina, United States
  • Wilson, North Carolina, United States
  • Canton, Ohio, United States
  • Maumee, Ohio, United States
  • Philadelphia, Pennsylvania, United States
  • Nashville, Tennessee, United States
  • Dallas, Texas, United States