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Sponsor: University Hospital, Toulouse
Conditions: Alzheimer Disease
Interventions: a positon emission tomography (PET) exam, MRI Contrast, oculometry assessment, cognitive exams
Countries: France
Alzheimer's disease (AD) is characterized by a long-lasting silent phase. Among initial events, emergence of tau pathology in locus coeruleus (LC) brainstem nucleus, well before the one observed in medial temporal cortex, is highly relevant. LC integrity and function can be assessed in vivo with MRI and pupil measures. The current research proposes to evaluate these LC markers in an aged healthy cohort (n=100, with half APOE4 positive) and to relate these markers with cerebral tau pathology, AD risk and cognitive function.
Sex: ALL
Age: 60 Years to 100 Years
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: * Participant in the INSPIRE-T cohort * Normal cognitive assessment * MMSE score ≥ 27 out of 30 (Mini-Mental State Examination) * Normal visual abilities (in corrected or uncorrected vision) * Normal motor skills Exclusion Criteria: * Subjects with a contraindication to MRI exam * Subjects with a known allergic reaction to the PET radiopharmaceutical (\[18F\] Flortaucipir) or any of its excipients * Subjects with an ophthalmological pathology making oculometric measurements difficult * Subjects with a neurodegenerative condition or a history of cerebral ischemia * Subjects with a psychiatric disorder and a PHQ-9 score \> 10 or under treatment with NRI
- Toulouse, France