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STN-tTIS Modulates Parkinson Motor Symptoms With and Without Medications

CompletedNA

Sponsor: Ruijin Hospital

Conditions: Parkinson Disease

Interventions: NervioX-2400

Countries: China

The goal of this clinical trial is to evaluate the immediate effects of individualized 130 Hz STN-tTIS(Subthalamic Nucleus - transcranial Temporal Interference Stimulation)on motor symptoms in early-to-mid-stage PD patients during both medication "on" and "off" states. The main questions it aims to answer are: 1. Does the therapeutic effect of STN - tTIS relate to medication? 2. The degree of improvement in motor symptoms of Parkinson's disease patients after STN - tTIS therapy under different medication conditions. Researchers compared the MDS - UPDRS - III improvement scores of tTIS therapy in the "on" and "off" medication phases to see if tTIS could work of independently medication. 1. Visit the clinic once every 1 weeks for therapy and test. 2. Record their symptoms and scores.

Eligibility overview

Sex: ALL

Age: 50 Years to 85 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* MDS diagnosis of primary Parkinson's disease
* Hoehn \& Yahr stage \< 3
* Antiparkinsonian drugs remained unchanged in the past four weeks and dosage remained unchanged during the study

Exclusion Criteria:

* Presence of neurological disorders that may affect the study (e.g., Traumatic brain injury)
* History of antipsychotics, antidepressants, or dopamine modulators other than PD drugs
* Metal devices in the head or heart (e.g., deep brain stimulators, pacemakers)
* Unstable vital signs

Locations (1)

Shanghai, Shanghai Municipality, China