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A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease
A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

NCT06830629

RecruitingPhase 2

Sponsor: Maze Therapeutics

Conditions: Proteinuric Kidney Disease

Interventions: MZE829

Countries: United States, France, United Kingdom

The purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease.

Eligibility overview

Sex: ALL

Age: 18 Years to 68 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Key Inclusion Criteria:

* APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2
* Chronic kidney disease with persistent albuminuria

Key Exclusion Criteria:

* Organ or bone marrow transplantation
* History of active cancer within past 2 years, except for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer
* Conditions that may alter drug absorption, e.g., history of bariatric surgery
* Type I diabetes
* Pregnant or currently nursing

Other inclusion/exclusion criteria defined in protocol apply.
Locations (79)
  • Decatur, Alabama, United States
  • Huntsville, Alabama, United States
  • Montgomery, Alabama, United States
  • Montgomery, Alabama, United States
  • Bloomfield, Connecticut, United States
  • Washington D.C., District of Columbia, United States
  • Atlantis, Florida, United States
  • Brandon, Florida, United States
  • Hollywood, Florida, United States
  • Melbourne, Florida, United States
  • Orlando, Florida, United States
  • Atlanta, Georgia, United States
  • College Park, Georgia, United States
  • Cordele, Georgia, United States
  • Macon, Georgia, United States
  • Riverdale, Georgia, United States
  • Riverdale, Georgia, United States
  • Savannah, Georgia, United States
  • Snellville, Georgia, United States
  • Chicago, Illinois, United States
  • Chicago, Illinois, United States
  • Evanston, Illinois, United States
  • Kansas City, Kansas, United States
  • Bowling Green, Kentucky, United States
  • Louisville, Kentucky, United States
  • Arnold, Maryland, United States
  • Lutherville, Maryland, United States
  • Oxon Hill, Maryland, United States
  • Dearborn, Michigan, United States
  • Flint, Michigan, United States
  • + 49 more on CT.gov