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Confocal Laser Endomicroscopy Guided Cryobiopsy in the Diagnosis of Interstitial Lung Disease

CompletedNA

Sponsor: China-Japan Friendship Hospital

Conditions: Interstitial Lung Disease (ILD)

Interventions: pCLE-guided transbronchial lung cryobiopsy, Fluoroscopy-guided transbronchial lung cryobiopsy

Countries: China

This prospective, single-center, randomized controlled trial compares pCLE-guided TBLC with conventional TBLC in patients with suspected interstitial lung disease. The study evaluates whether pCLE guidance improves diagnostic performance and procedural safety, with outcomes including final diagnosis and biopsy-related complications.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Eligibility Criteria：

1. adults with suspected interstitial lung disease (ILD).
2. Clinical and HRCT findings insufficient to establish a definitive diagnosis.
3. Histopathological evaluation by TBLC considered necessary after multidisciplinary discussion.
4. Age ≥18 years
5. Written informed consent provided.

Exclusion Criteria:

1. Contraindications to bronchoscopy or TBLC.
2. Severe hypoxemia or uncontrolled bleeding risk.
3. Severe pulmonary hypertension or unstable cardiopulmonary disease.
4. Active infection.
5. Pregnancy.
6. Inability to provide informed consent.

Locations (1)

Beijing, China