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Project QUIT+: Adapting and Testing a Smoking Cessation Intervention for Transgender and Gender Expansive Individuals

TerminatedNA

Sponsor: Massachusetts General Hospital

Conditions: Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress

Interventions: PRIDE QUIT, Enhanced Treatment As Usual (ETAU)

Countries: United States

Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors likely contribute to these disparities, and the increased burden of gender minority stress may also be driving higher prevalence rates of anxiety and depression, both of which are more common among TGD individuals and among those who smoke relative to comparison samples. This study will (1) explore the ways in which gender minority stressors and associated anxiety and depression compromise smoking cessation among TGD individuals, identifying elements in an existing smoking cessation intervention that need to be adjusted to meet their unique needs; (2) adapt an existing smoking cessation intervention for TGD individuals; and (3) evaluate the feasibility and acceptability of the adapted intervention in a pilot randomized controlled trial.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* aged 18+
* self-reported difference between sex assigned at birth and gender identity
* current use of combustible cigarettes OR recent use of combustible cigarettes (defined as at least 5 cigarettes-per-day at some point within the past 6 months) OR current use of nicotine-containing e-cigarettes with use of combustible cigarettes in the past 6 months (defined as 5 cigarettes-per-day)
* English-speaking.

Exclusion Criteria:

* unable to provide informed consent
* current interfering untreated or unstable major health condition that is event during screening (e.g., active mania, current psychosis)

Locations (3)

Boston, Massachusetts, United States
Boston, Massachusetts, United States
Boston, Massachusetts, United States