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Inclusion Criteria:

* Have a diagnosis of Chronic Kidney Disease (CKD) based on eGFR category and albuminuria category per the Kidney Disease: Improving Global Outcomes (KDIGO) criteria
* Have been on a maximally tolerated labeled daily dose of an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB) for 90 days preceding screening and is expected to remain on a stable regimen through the study
* If on additional treatment for CKD, must be on stable dose for at least 90 days before screening.
* If diagnosed with Type 2 Diabetes, should be on stable antihyperglycemic treatment for at least 90 days before screening.

Exclusion Criteria:

* Have any one of the following cardiovascular conditions 90 days prior to screening:

  * myocardial infarction
  * stroke
  * hospitalization or urgent visit for heart failure, and
  * coronary, carotid, or peripheral artery revascularization.
* Have a documented New York Heart Association (NYHA) Class IV heart failure at the time of screening.
* Have chronic or intermittent hemodialysis or peritoneal dialysis 90 days prior to screening.
* Have acute dialysis or acute kidney injury 90 days prior to screening.
* Have a history of a congenital or hereditary kidney disease, polycystic kidney disease, lupus nephritis, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and nephrotic syndrome
* Requires chronic immunosuppression.
* Have HbA1c \>8.5% at screening
* Have had a transplanted organ or are awaiting an organ transplant
* Have a diagnosis or history of malignant disease within 5 years prior to baseline.
* Have symptomatic hypotension.
* Have acute or chronic hepatitis.

• Downey, California, United States
• Evergreen Park, Illinois, United States
• Hinsdale, Illinois, United States
• Huntley, Illinois, United States
• Fort Wayne, Indiana, United States
• Indianapolis, Indiana, United States
• Metairie, Louisiana, United States
• Flint, Michigan, United States
• Greenville, North Carolina, United States
• Jacksonville, North Carolina, United States
• Kinston, North Carolina, United States
• Morehead City, North Carolina, United States
• New Bern, North Carolina, United States
• Wilmington, North Carolina, United States
• Houston, Texas, United States
• Odessa, Texas, United States
• Gosford, New South Wales, Australia
• Liverpool, New South Wales, Australia
• Parkville, Victoria, Australia
• Murdoch, Western Australia, Australia
• Beijing, Beijing Municipality, China
• Beijing, Beijing Municipality, China
• Taian, Shandong, China
• Yantai, Shandong, China
• Ningbo, Zhejiang, China
• Ningbo, Zhejiang, China
• Kamakura-shi, Kanagawa, Japan
• Niigata, Japan
• Okayama, Japan
• A Coruña, A Coruña [La Coruña], Spain
• + 5 more on CT.gov