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A Study in Participants With Obesity or Overweight With at Least One Weight-related Comorbidity
A Study in Participants With Obesity or Overweight With at Least One Weight-related Comorbidity

NCT06595238

CompletedPhase 2

Sponsor: AstraZeneca

Conditions: Obesity or Overweight

Interventions: AZD6234, Placebo comparator

Countries: United States, Australia, Canada, Japan, United Kingdom

A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of AZD6234 compared with placebo, given once a week as subcutaneous injection for 36 weeks, in male and female participants of at least 18 years of age who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2), or overweight (BMI ≥ 27 kg/m2) and at least one weight-related comorbidity

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Adults ≥ 18 years of age
* BMI of (a) ≥ 30 kg/m2, or (b) ≥ 27kg/m2 and have a current diagnosis of at least 1 weight-related comorbidities (treated or untreated)
* A stable body weight for 3 months prior to Screening (±5% body weight change)

Exclusion Criteria:

* Have obesity induced by other endocrine disorders, such as Cushing's syndrome or Prader-Willi syndrome
* Has received prescription or non-prescription medication for weight loss within the last 3 months prior to Screening
* Previous or planned (within study period) bariatric surgery or fitting of a weight loss device (eg, gastric balloon or duodenal barrier)
* History of type 1 diabetes mellitus or T2DM
Locations (41)
  • Mobile, Alabama, United States
  • Phoenix, Arizona, United States
  • Long Beach, California, United States
  • Hialeah, Florida, United States
  • Largo, Florida, United States
  • Orlando, Florida, United States
  • Tampa, Florida, United States
  • Woodstock, Georgia, United States
  • Indianapolis, Indiana, United States
  • Lutherville-Timonium, Maryland, United States
  • Gulfport, Mississippi, United States
  • Ridgeland, Mississippi, United States
  • Kansas City, Missouri, United States
  • Omaha, Nebraska, United States
  • Portsmouth, New Hampshire, United States
  • Statesville, North Carolina, United States
  • North Charleston, South Carolina, United States
  • Knoxville, Tennessee, United States
  • Austin, Texas, United States
  • Dallas, Texas, United States
  • Port Arthur, Texas, United States
  • San Antonio, Texas, United States
  • San Antonio, Texas, United States
  • Heidelberg, Australia
  • Maroochydore, Australia
  • Maroubra, Australia
  • Merewether, Australia
  • Hamilton, Ontario, Canada
  • Sarnia, Ontario, Canada
  • Stouffville, Ontario, Canada
  • + 11 more on CT.gov