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Predicting Cognition After DBS for Parkinson's Disease 2

Active Not RecruitingN/A

Sponsor: Charite University, Berlin, Germany

Conditions: Cognitive Impairment

Interventions: Neuropsychological Testing

Countries: Germany

The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management and personalize therapeutic strategies for optimal long-term benefit. The investigators will test possible predictors (clinical, neuropsychological, neuroimaging, electrophysiological and molecular) for the risk of cognitive dysfunction after deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) at a single center (Charité - Universitätsmedizin Berlin, Germany). Data collection takes place prior to as well as 3, 12 and 60 months after the STN-DBS operation. Participation is proposed to all PD patients that are planned to undergo STN-DBS after careful examination of eligibility for this treatment according to standard operation procedures.

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosis of idiopathic Parkinson's Disease
* Indication for STN-DBS

Exclusion Criteria:

* Internistic, surgical or psychiatric contrainidications with respect to the DBS operation or treatment for the STN-DBS group
* Dementia
* Relevant language barrier

Locations (1)

Berlin, Germany