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Sponsor: Fenway Community Health
Conditions: HIV Infections, Adherence, Medication
Interventions: PrEP4T, LS4TM
Countries: United States
Transgender masculine and gender diverse people who have sex with men (TMSM) have an increased risk of human immunodeficiency virus (HIV) and face unique barriers engaging in prevention services. Digitally delivered support interventions addressing HIV prevention barriers delivered by peers in one-on-one or small-group settings may be effective at increasing pre-exposure prophylaxis (PrEP) engagement for HIV prevention. This study examines the independent and combined effects of individual and group-based peer-support interventions on PrEP outcomes. Participants will be randomly assigned to receive: (i) standard-of-care HIV prevention information, (ii) a one-on-one healthy lifestyle intervention tailored for transgender masculine people, (iii) a peer-group based healthy lifestyle intervention for transgender masculine people, or (iv) both the one-on-one and group-based interventions delivered together. The hypotheses are that the individual group-based interventions will result in higher PrEP uptake and persistence than the standard of care and that the combined interventions will be more effective than receiving one individual intervention.
Sex: MALE
Age: 18 Years to —
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: * Age 18 or over * Identifies as a man, trans man, or another transmasculine identity * Has had sex with a partner assigned male sex at birth with a flesh penis in the last 3 months * Has access to a smartphone or computer with internet access * Is HIV-uninfected * Resides in one of the Ending the Epidemic targeted geographic hotspots in the United States * Willing and able to provide informed consent in English * Meets CDC guidelines for PrEP indications in the last 3 months (adapted for TMSM) including: * Condomless receptive vaginal/frontal or anal sex with a partner assigned male at birth with a flesh penis * Sharing needles or syringes for illicit drug use and/or hormones * Self-reported anogenital sexually transmitted infection diagnosis Exclusion Criteria: * Less than age 18 * Does not identify as a man, trans man, or another transmasculine identity * Does not have access to a smartphone or computer * Is living with HIV (HIV positive) * Does not reside in one of the Ending the Epidemic geographic hotspots in the United States * Will not or cannot provide written informed consent in English * Does not meet the trans-adapted CDC guidelines for PrEP indications
- Boston, Massachusetts, United States