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Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection

CompletedPhase 4

Sponsor: University of California, Irvine

Conditions: Intestinal Disease

Interventions: Neostigmine Injectable Solution, Sugammadex injection

Countries: United States

The purpose of this research study is to see the outcome of Sugammadex versus Neostigmine with Glycopyrrolate in colorectal surgery as it relates to its effects on post-surgical time (in hours) to first bowel movement and tolerance for solid food (GI-2 recovery) following bowel resection surgery

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age 18 or older
* Laparoscopic bowel resection surgery under general anesthesia with nondepolarizing neuromuscular blockade with rocuronium or vecuronium, and requiring inpatient admission

Exclusion Criteria:

* Allergy to Rocuronium, Vecuronium, or Sugammadex
* Bowel resection surgery requiring an ostomy
* No severe valvulopathy, no systolic heart failure with reduced ejection fraction (HFrEF), no coronary artery disease with positive stress test for ischemic regional wall motion abnormality
* No autoimmune pulmonary disease, no severe pulmonary fibrosis, no severe pulmonary hypertension, no COPD with requirement of home oxygen, no pulmonary cancer of primary or metastatic origin
* Creatinine Clearance (CrCl) of less than 30
* Pregnancy
* Incapable of providing consent or understanding the research project

Locations (1)

Orange, California, United States