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Zinc Supplementation Prior to Botox Injections for Spasmodic Dysphonia

CompletedPhase 1, Phase 2

Sponsor: University of Florida

Conditions: Spasmodic Dysphonia

Interventions: Zinc gluconate supplement, Botulinum toxin type A

Countries: United States

One initial study has shown that Botulinum Toxin (BT) in combination with zinc supplementation may increase the duration of effects BT treatment. This initial study was in the context of facial aesthetics. The purpose of the present study is to determine the effect, if any, of oral zinc supplementation prior to BT in the treatment of spasmodic dysphonia. If positive effects will be observed, this would help reduce the burden of disease for these patients.

Eligibility overview

Sex: ALL

Age: 18 Years to 99 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Adults patients
* 18 years old and above
* Current diagnosis of ADductor spasmodic dysphonia
* Has had Botox injection treatments for SD \> 6 months

Exclusion Criteria:

* Pregnant
* Diagnosis of ABductor spasmodic dysphonia
* Patients taking \> 30 mg zinc supplementation daily prior to study beginning

Locations (1)

Gainesville, Florida, United States