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Diagnosing Variable Primary Aldosteronism.

RecruitingN/A

Sponsor: Queen Mary University of London

Conditions: Primary Aldosteronism, High Blood Pressure

Countries: United Kingdom

The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
* Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
* Patients with aldosterone results done at different times that indicate variability in production.
* Willing to consent and participate in the study.

Exclusion Criteria:

* Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
* People on end of life treatment.

Locations (1)

London, United Kingdom