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Neuro-affective Response to Light in Depressed Adolescents and Young Adults

Active Not RecruitingNA

Sponsor: University of Pittsburgh

Conditions: Depression in Adolescence, Depression in Adults

Interventions: Blue Light, Red Light

Countries: United States

The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults? Participants will complete: * A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses. * A pupillometry test of sensitivity to blue vs red light * Clinical interviews and surveys * Screening measures for drug and alcohol use, MRI safety, and current pregnancy \[if relevant\] * Home sleep tracking with sleep diary and actigraphy for one week

Eligibility overview

Sex: ALL

Age: 12 Years to 30 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Elevated Depressive Symptoms \[PHQ9≥5 And (Item 1≥1 or Item 2≥1)\]
* (If \<18yr) Parent or guardian can attend the baseline clinical interview

Exclusion Criteria:

* Unable to read and write in English
* Intellectual disability.
* Left or mixed handedness
* Changes to psychotropic medication type or dosage in the past 2 months
* Lifetime bipolar disorder or schizophrenia, or substance/alcohol disorder in the past 3 months.
* Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).
* Factors influencing the ability to maintain a stable sleep schedule (i.e., shift work, severe sleep disorders, extremely late or early sleep schedule).
* Severe medical illness, neurological disorders, or history of head trauma.
* Current pregnancy or nursing
* MRI contraindication (e.g., metals in the body, recent tattoo, claustrophobia)
* Positive alcohol or substance use screen at MRI visit

Locations (1)

Pittsburgh, Pennsylvania, United States