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A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

RecruitingNA

Sponsor: Mayo Clinic

Conditions: Lung Transplant

Interventions: Off-pump lung transplantation, Venoarterial ECMO lung transplantation

Countries: United States, Belgium

The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which technique has lower rates of primary graft dysfunction.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Bilateral Lung Transplantation (LTx) recipients.
* Mean pulmonary artery pressure \< or = 35 mmHg.
* Eligible for off-pump or VA ECMO based on the judgement of the attending surgeon.

Exclusion Criteria:

* Single lung transplant
* Multiorgan transplant.
* Donor after cardiac death (DCD).
* Re-transplant.
* Intention to use prophylactic post-operative ECMO.
* Previous major lung surgery. Video-assisted thoracoscopic surgery (VATS) and wedge resection are not an exclusion criterion.
* Previous pleurodesis.
* Preoperative ECMO and/or mechanical ventilation.

Locations (10)

Los Angeles, California, United States
Atlanta, Georgia, United States
Louisville, Kentucky, United States
Baltimore, Maryland, United States
Rochester, Minnesota, United States
Columbus, Ohio, United States
Philadelphia, Pennsylvania, United States
Dallas, Texas, United States
Houston, Texas, United States
Leuven, Belgium