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Early Human Milk Fortification After Early, Exclusive, Enteral Nutrition in Very Preterm Infants

Active Not RecruitingNA

Sponsor: University of Alabama at Birmingham

Conditions: Prematurity, Light-For-Dates, Enteral Feeding Intolerance

Interventions: Early HMF, Delayed HMF

Countries: United States

In this proposed clinical trial, the investigators will randomize 80 very preterm (VPT) infants to receive either early (between day 4 and 7) or delayed (between day 10 and 14) fortification and determine if providing early protein supplementation through early fortification results in higher FFM-for-age z scores and more diversity in the gut microbiome.

Eligibility overview

Sex: ALL

Age: 1 Day to 4 Days

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Gestational age 29 to 33 weeks of gestation
* Birth weight \< 1800 g
* Postnatal age \< 96 hours

Exclusion Criteria:

* Small for gestational age (\<5th percentile)
* Major congenital/chromosomal anomalies
* Terminal illness needing withhold or limit support

Locations (1)

Birmingham, Alabama, United States