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Neuroimaging Sleep and Mood in Depression

CompletedNA

Sponsor: Boston University Charles River Campus

Conditions: Major Depression

Interventions: Sleep deprivation

Countries: United States

This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion criteria:

* Adult aged 18-80

Inclusion criteria for patient cohort only:

\- Current diagnosis of major depressive disorder

Exclusion criteria:

* Must not have ferrous metal implanted in head or body
* Must have no history of major head trauma
* Must not have implanted electronic devices (e.g., pacemaker, neurostimulator)
* Must not be pregnant, suspect they are pregnant, or seeking to become pregnant
* Must not be claustrophobic
* Must have no piercings or jewelry that cannot be removed
* Weight less than 250 pounds
* No lifetime history of schizophrenia or any other psychosis disorder, substantial intellectual disability, bipolar disorder, post-traumatic stress disorder or obsessive compulsive disorder
* No alcohol or substance abuse or dependence within the past 6 months
* No significant personality dysfunction
* Must not indicate significant suicide risk.
* Must not be taking medications that significantly affect sleep, psychiatric function, blood/vascular function, or anti-inflammatory medications (other than minor NSAID use).

Locations (1)

Boston, Massachusetts, United States