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Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

Active Not RecruitingNA

Sponsor: Vanderbilt University Medical Center

Conditions: Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection

Interventions: Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation

Countries: United States

The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Prior RT-PCR-confirmed COVID-19 infection.
* Post-COVID-19 POTS will be defined as the presence of orthostatic tachycardia (\>30 bpm) and chronic (\>3 months) pre-syncopal symptoms.

Exclusion criteria:

* Heart Disease: Myocardial Infarction, angina, heart failure
* History of stroke, or transient ischemic attack
* Undergone an invasive procedure for CVD (coronary artery bypass graft, angioplasty, valve replacement, pacemaker placement or other vascular surgeries)
* Uncontrolled hypertension defined as persistent blood pressure \>140/90.
* Post-menopausal women.
* Diabetes Mellitus Type 1 or Type 2. ,
* Impaired Hepatic function
* Impaired renal function test (eGFR\<60 mL/min/1.73m2).
* Ongoing substance abuse.
* Mental conditions rendering a subject unable to understand the nature, scope and possible consequences of the study.
* History of seizures.
* Chronic use of steroids, NSAIDs.
* On biologics such as anti-IL6 (omalizumab) and anti-TNF-alpha drugs
* Pregnancy or breastfeeding

Locations (1)

Nashville, Tennessee, United States