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Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

NCT05194098

CompletedNA

Sponsor: San Francisco Veterans Affairs Medical Center

Conditions: Major Depressive Disorder

Interventions: TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil, SHAM (inactive) TMS stimulation

Countries: United States

Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

• Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.

Inclusion Criteria:

* All participants

  * 18-65 years old
  * Normal (or corrected to normal) vision
* Participants with MDD

  * Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD
  * Screened for TMS and MRI safety
  * On a stable psychiatric medication regime for \> 1 month

Exclusion Criteria (all participants):

* Premorbid IQ estimate \< 70
* Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
* Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
* Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)
* Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
* Known claustrophobia
* Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)

Exclusion criteria (Participants with MDD only)

* Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis
* Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis
* Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)
* Past or present DSM-5 (SCID-5) Gambling Disorder

Exclusion Criteria (HCs only)

• DSM-5 (SCID-5) criteria for any psychiatric disorder

Locations (1)

San Francisco, California, United States