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Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity

CompletedNA

Sponsor: Universidade do Porto

Conditions: Obesity, Weight Loss

Interventions: Intermittent energy restriction (IER), Continuous energy restriction (CER)

Countries: Portugal

One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain. Therefore, the aim of this study is to evaluate the effects of an intermittent versus a continuous energy restriction in body composition (body weight, fat mass and fat-free mass) and metabolic adaptation, in women with obesity.

Eligibility overview

Sex: FEMALE

Age: 20 Years to 45 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Women
* BMI ranging between 30 and 39.9 kg/m2
* Age between 20-45 years
* Weight stable in the last 6 months (less than 5% weigh variation)
* Inactive (less then 150 min/week of moderate physical activity or 75 min/week of vigorous physical activity
* Living in Lisbon Metropolitan Area and being able to drive to Faculty of Human Kinetics and Germano de Sousa Laboratory (Algés)
* Available to be randomized to any of the trial groups (CER or IER)
* Willing to commit with the assigned group protocol, including the nutritional intervention and lifestyle recommendations, as well as being available for participation in all evaluation moments.

Exclusion Criteria:

* Previous or present health disorders: cancer, autoimmune, cardiac, psychiatric, kidney and liver disease (except liver steatosis), diabetes, chronic intestinal inflammatory disease, or other medical conditions known to affect energy balance homeostasis
* Menopause
* Hormonal or thyroid disorder
* Medications that promote weight gain or alter energy balance, including corticosteroids, antidepressants, anxiolytics, mood-stabilizing, and antipsychotics
* Medications or dietary supplements for weight-loss in the past 3 months
* Pregnant for the past 6 months or breastfeeding
* Planning to get pregnant in the next 2 years or getting pregnant during the study
* Current consumption of more than 14 alcoholic drinks per week or other substance abuse, and/or current acute treatment or rehabilitation program for alcohol/substance abuse
* Surgery or in hospital admission for the last month
* Positive for Covid-19 in the past 3 months or testing positive during the intervention phase of the study

Locations (1)

Cruz Quebrada, Lisbon District, Portugal