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Falls: A Marker of Preclinical AD

CompletedN/A

Sponsor: Washington University School of Medicine

Conditions: Fall, Alzheimer Disease

Countries: United States

This longitudinal cohort study investigates cognitively normal participants with and without preclinical Alzheimer disease (AD) in order to examine: (1) the relationship between falls and functional mobility in preclinical stages of AD; and (2) a hypothesized model of central and peripheral mechanism(s) underlying falls and functional mobility in preclinical stages of AD.

Eligibility overview

Sex: ALL

Age: 65 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. 65 years of age or older
2. cognitively normal (Clinical Dementia Rating \[CDR\] score of 0)

   * A pilot sub-study collecting stool will also enroll a few individuals with CDR\>0 for comparison.
3. have biomarkers (CSF), and/or neuroimaging (positron emission tomography \[PET\] and/or magnetic resonance imaging \[MRI\]) within 2 years of enrolling in this study.

Exclusion Criteria:

* History of Parkinson's disease.

Locations (1)

St Louis, Missouri, United States