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Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion

Active Not RecruitingN/A

Sponsor: Milton S. Hershey Medical Center

Conditions: Concussion, Mild

Countries: United States

The purpose of this study is to identify changes in salivary micro ribonucleic acid (miRNA) levels that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.

Eligibility overview

Sex: ALL

Age: 5 Years to 24 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Presence of mTBI: defined by criteria from the Berlin Consensus Statement and WHO. Assessment for mTBI status be performed by a licensed clinician per the 2018 CDC guidelines.
* Age at enrollment: 5-24 years of age (inclusive).

Exclusion Criteria:

* \>7d after initial mTBI
* Glasgow Coma Scale score of 13 or less
* Previous moderate-to-severe TBI requiring overnight hospitalization
* Unresolved symptoms from previous concussion, or any concussion within the last 3 months
* Abbreviated Injury Scale (AIS) score \> 3 (to reduce confounding from poly-trauma)
* Psychiatric illness requiring previous hospitalization;
* Neurological condition (e.g. epilepsy, hydrocephalus) or abnormality on neuroimaging (if performed)
* Intellectual disability that prevents ability to provide informed assent
* Pregnancy
* Active substance use/dependence
* Previous neurosurgery
* Non-fluency in English
* Upper respiratory infection
* Periodontal infection
* Injury to the oropharynx
* Previously enrolled in the same study
* Inability to complete follow-up assessments

Locations (5)

Boston, Massachusetts, United States
New York, New York, United States
Syracuse, New York, United States
Cincinnati, Ohio, United States
Hershey, Pennsylvania, United States