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Effect of NMN Supplementation on Organ System Biology

CompletedNA

Sponsor: Washington University School of Medicine

Conditions: Glucose Metabolism Disorders

Interventions: Placebo, Treatment

Countries: United States

The goal of this proposal is to determine whether the beneficial effects of NMN on metabolic function observed in rodents applies to people.

Eligibility overview

Sex: ALL

Age: 45 Years to 75 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* BMI 25.0-50.0 kg/m²
* Prediabetes defined as fasting plasma glucose of ≥100 mg/dL, or HbA1C ≥5.7, or HOMA-IR ≥2.5.

Exclusion Criteria:

* Women who are still having menses
* Persons who take niacin, nicotinamide, or other vitamin B3-related supplementation and are not willing to discontinue supplementation for 3 weeks before medical screening and during the entire study period
* Persons who consume moderate-large amounts of caffeine daily (\>2 cups of coffee or 8 oz caffeinated drinks per day) or consume less amounts of caffeine but believe withdrawal symptoms (e.g. headache) are likely if caffeine is stopped
* Unstable weight (\>3% change during the last 2 months before entering the study)

Locations (1)

St Louis, Missouri, United States