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Sponsor: University Hospital, Strasbourg, France
Conditions: Alzheimer Disease, Fronto-temporal Lobar Dementia
Interventions: Questionnary and IRM
Countries: France
The aim of this study is to characterize the deficit in critical components of personal identity (self-consciousness and social cognition) in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study. We posit that the alteration of some aspects of self-consciousness (autobiographical memory, nosognosia, metacognition) and social cognition (theory of mind and facial) results in personality changes in the patients, primarily due to the alteration of self-consciousness in AD and to social cognition in FTLD.
Sex: ALL
Age: 45 Years to 85 Years
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: * AD (McKhann et al, 1984 and Dubois et al, 2007) or FTLD (Neary et al, 1998 or Rascovsky et al, 2011) * MMSE \> or = 18 * Relative avaible Exclusion Criteria: * Contraindication to MRI * Major depression * Other central neurological condition
- Strasbourg, France