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Dominantly Inherited Alzheimer Network (DIAN)
Dominantly Inherited Alzheimer Network (DIAN)

NCT00869817

RecruitingN/A

Sponsor: Washington University School of Medicine

Conditions: Alzheimer's Disease

Countries: United States, Argentina, Australia, Brazil, Canada, Colombia, Germany, Japan

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria
Inclusion Criteria:

* Written informed consent obtained from participant and collateral source prior to any study-related procedures.
* Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
* Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
* Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
* Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.

Exclusion Criteria:

* Under age 18
* Medical or psychiatric illness that would interfere in completing initial and follow-up visits
* Requires nursing home level care
* Has no one who can serve as a study informant
Locations (26)
  • Jacksonville, Florida, United States
  • Indianapolis, Indiana, United States
  • Boston, Massachusetts, United States
  • St Louis, Missouri, United States
  • New York, New York, United States
  • Pittsburgh, Pennsylvania, United States
  • Providence, Rhode Island, United States
  • Seattle, Washington, United States
  • Salta, Salta Province, Argentina
  • Buenos Aires, Argentina
  • Sydney, New South Wales, Australia
  • Melbourne, Victoria, Australia
  • Perth, Western Australia, Australia
  • São Paulo, São Paulo, Brazil
  • Verdun, Quebec, Canada
  • Medellín, Colombia, Colombia
  • Munich, Germany
  • Tübingen, Germany
  • Niigata, Japan
  • Osaka, Japan
  • Tokyo, Japan
  • Mexico City, Mexico City, Mexico
  • Amsterdam, Netherlands
  • Seoul, Songpa-Gu, South Korea
  • Barcelona, Catalonia, Spain
  • London, United Kingdom