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Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema
Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema

NCT00817063

CompletedPhase 3

Sponsor: Stiefel, a GSK Company

Conditions: Eczema

Interventions: alitretinoin, Placebo

Countries: United States

The purpose of this study is to investigate the safety and efficacy of alitretinoin in the treatment of severe chronic hand eczema that does not respond to treatment with potent topical steroids.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* all types of chronic hand eczema, lasting for at least 6 months since initial diagnosis
* rated as severe by the physician
* unresponsive to highly potent topical corticosteroids, such as clobetasol

Exclusion Criteria:

* patients whose disease is adequately controlled by standard non-medicated therapy, including potent topical steroids, skin moisturizers, and avoidance of allergens and irritants
* patients with known allergens and irritants, who have not made a reasonable effort to avoid the substances
* patients with psoriasis lesions
* active fungal, bacterial or viral infections of the hands
* female patients who are pregnant or breastfeeding
* female patients of childbearing potential who cannot use or will not commit to use two effective methods of contraception
Locations (70)
  • Birmingham, Alabama, United States
  • Tucson, Arizona, United States
  • Fort Smith, Arkansas, United States
  • Little Rock, Arkansas, United States
  • Rogers, Arkansas, United States
  • Encino, California, United States
  • La Jolla, California, United States
  • Los Angeles, California, United States
  • Marina del Rey, California, United States
  • Riverside, California, United States
  • Sacramento, California, United States
  • San Diego, California, United States
  • San Ramon, California, United States
  • Stanford, California, United States
  • Vallejo, California, United States
  • Longmont, Colorado, United States
  • Wheat Ridge, Colorado, United States
  • Washington D.C., District of Columbia, United States
  • Orange Park, Florida, United States
  • West Palm Beach, Florida, United States
  • Toccoa, Georgia, United States
  • Nampa, Idaho, United States
  • Arlington Heights, Illinois, United States
  • Belleville, Illinois, United States
  • Schaumburg, Illinois, United States
  • West Dundee, Illinois, United States
  • Evansville, Indiana, United States
  • Indianapolis, Indiana, United States
  • New Albany, Indiana, United States
  • Plainfield, Indiana, United States
  • + 40 more on CT.gov