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Inclusion Criteria:

* Male or female subjects at least 12 years old and in good general health.
* Mild to moderate plaque-type psoriasis

Exclusion Criteria:

* Known allergy or other adverse reaction to calcipotriene or other vitamin D analogs; or to any component of the investigational formulations
* History of hypercalcemia or of vitamin D toxicity.
* Diagnosis of generalized pustular or erythrodermic exfoliative psoriasis.
* Other serious skin disorder or any chronic medical condition that is not well controlled.
* Use of non-biologic systemic anti-psoriatic therapy or biologic therapy within four weeks of enrollment.
* Use of topical therapies that have a known beneficial effect on psoriasis, within 2 weeks of enrollment.
* Systemic medications for other medical conditions that are known to affect psoriasis within the past four weeks of enrollment.
* Use of any investigational therapy within 4 weeks of enrollment.
* Pregnant women, women who are breast feeding, or sexually active women of child bearing potential who are not practicing an acceptable method of birth control.

• San Diego, California, United States
• Denver, Colorado, United States
• Miami, Florida, United States
• Miami, Florida, United States
• Louisville, Kentucky, United States
• Boston, Massachusetts, United States
• Fridley, Minnesota, United States
• New York, New York, United States
• High Point, North Carolina, United States
• Portland, Oregon, United States
• Dallas, Texas, United States
• Houston, Texas, United States
• Salt Lake City, Utah, United States