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Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression

CompletedNA

Sponsor: Douglas Mental Health University Institute

Conditions: Bipolar Type II Disorder, Depression, Bipolar

Interventions: Northern Light Technology (SADelite lamp) bright light-therapy, Northern Light Technology (SADelite lamp) Dim light-therapy

Countries: Canada

The purpose of this study is to evaluate the efficacy and safety of light therapy for the treatment of bipolar type II patients relapsing into a depressive phase during autumn or winter.

Eligibility overview

Sex: ALL

Age: 18 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Bipolar type II disorder, depressive phase meeting DSM-IV criteria as per the SCID interview
* Hamilton Depression Rating Scale 21 items (HAMD-21) ≥ 17 and a Montgomery Asberg rating Scale (MADRS) ≥ 15 for at least 2 weeks and the episode has begun during the month of september or a later month
* Able to give their consent and willingness to participate to the study

Exclusion Criteria:

* Other psychiatric condition, organic brain disorder, unstable and/or untreated medical condition such as hypothyroidism, diabetes, cardiac condition, hypertension
* Deficit in vitamin B12 or folate
* Sub-syndromic hypomania symptoms as per a Young Mania Rating Scale (YMRS) score ≥ 4
* History of manic or hypomanic switch when exposed to bright light or during prolonged exposure to the sun during previous depressive phases
* Pregnancy or absence of a contraceptive treatment
* History of light-induced migraine or epilepsy
* Marked suicidal ideation
* Retinal blindness or severe cataract
* Glaucoma, retinal diseases of the eye
* Alcohol or drug abuse
* Known skin sensitivity to sunlight, especially in patients receiving photosensitizing drugs such as lithium or phenothiazines
* Past history of light therapy

Locations (1)

Montreal, Quebec, Canada