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Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin

TerminatedPhase 4

Sponsor: Derm Research @ 888 Inc.

Conditions: Acne Vulgaris

Interventions: Minocycline, Minocycline plus tretinoin

Countries: Canada

The use of oral antibiotics alone to treat inflammatory acne provides little to no long term therapeutic benefit. Acne relapse rates can be reduced by using topical tretinoin 0.01% in conjunction with minocycline, thereby increasing the therapeutic effect of the oral antibiotic.

Eligibility overview

Sex: ALL

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Provision of written consent
* Either sex
* Any age
* Diagnosis of acne vulgaris with a minimum of 20 inflammatory acne lesions on the face.

Exclusion Criteria:

* Known hypersensitivity to tetracyclines
* Use of any oral antibiotics in the previous 3 months
* Pregnancy, breast-feeding or lactating
* Inability or unwillingness to comply with the requirements of the protocol, or agree to the use of their data as determined by the investigator.
* Concomitant medical condition which, in the investigator's opinion, may confound the study results or interfere with study assessments or outcomes.
* Patients with severe acne on the chest, back or trunk.

Locations (1)

Vancouver, British Columbia, Canada